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Subject: Neotigason/Soriatane/Acitretin side effects
Topic
Area: Psoriasis
Forum: The Dermatology Forum
Question Posted By: Mark Shaw on Thursday, February 24, 2000
I live in the U.K. I am 28. and I've had severe psoriasis
for over 15 yrs. I have been taking Neotigason/Soriatane/Acitretin for 7
months, and had very good response, my psoriasis completely
cleared.
However I was on a dosage of 60mg/day, and just before
Christmas I was suddenly hit by the side effects below, which became
intolerable. I found I could only tolerate the side effects by taking
25mg/day, however the psoriasis is creeping back, so I'm trying to
increase the dosage slowly.
-- Worst --
1) Skin is cold/clammy
-can't get warm, becoming intolerable.
2) Cheilitis -Dry/Badly
peeling lips.
3) Dry/Badly peeling palms of hands, soles of feet,
skin around eyes.
-- Moderate --
4) Abnormal Skin odor.
5)
Sticky skin all over body.
6) Thin and splitting finger & toe
nails.
7) Paresthesia -Feeling of waves pin pricks running along my
body.
-- Minor--
8) Sore/dry eyes
9) Sore/dry
nostrils.
10) Hair on head turned curly.
11) Alopecia -Hair loss
all over body (Including scalp initially).
12) Hair colour turned
much lighter (initially).
I was hopping that you could suggest
anything to help reduce the cold skin feeling, and if possible any of
the others, apart from the obvious of moisturizers etc.
My
dermatologist doesn't acknowledge these as side effects, and I'd feel
uncomfortable correcting him.
This is the web site of Roche who
manufactures the drug, here you can see a list of side
effects.
http://www.rocheusa.com/products/soriatane/pi.html#ADVERSE
EVENTS
Many Thanks,
Mark.
Answer Posted By: Derm M.D. ASR
on Monday, February 28, 2000
Mark:
Unfortunately, I have almsot no clinical
experience with this drug and am quite unfamiliar with it. In any case,
most side-effects of the kind you list are dose-related. This means that
you can take only the does which produces side-effects which are
tolerable. Why you can suddenly tolerate less than half what you used to
take I cannot explain.
Sorry I cannot be of more
help.
Best.
Dr. R
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